Dados do Trabalho

Título

BIFIDOBACTERIUM SPP. AND ITS INFLUENCE ON INFLAMATORY PATHWAYS IN CELIAC DISEASE INDUCED BY DIVERSE PEPTIDES

Introdução

Celiac disease (CD) is an immune-mediated systemic disorder triggered by gluten peptides present in the diets of genetically susceptible individuals, leading to a range of intestinal and extra-intestinal manifestations. It is managed by a gluten-free diet (GFD). Despite apparent dietary compliance, symptoms persist in 30-50% of treated individuals. This study aimed to discuss the potential mechanisms of action by which bifidobacteria can mediate cytotoxic and proinflammatory responses induced by peptides triggering CD.

Material e Métodos

Initially, 2,069 documents were retrieved. These results were imported into the Mendeley reference manager, and subsequent steps - duplicate exclusion of 42 articles - were conducted using this platform. Upon reviewing titles, abstracts, and keywords, 2,027 documents were excluded due to non-compliance with inclusion criteria or alignment with exclusion criteria. Another 7 studies were eliminated as they were out of scope, and 2 because they involved non-adult individuals. In addition, 2 studies lacked full access to their complete documents despite their relevance to the topic. Finally, 10 studies were included for review.

Resultados e Discussão

The mechanisms mediated by bifidobacteria identified until now are 6 and include (1) induction of COX-1 expression in Caco-2 cells and reduction of COX-2 expression, ensuring intestinal mucosa integrity, (2) decreased zonulin activation and inhibition of CXCR3 mRNA expression, preventing tight junction breakdown, (3) hydrolysis of gliadin-derived peptides, preventing excess gluten peptides in the intestinal lumen, (4) and (5) control of the Th1 response and reduction of TNF-α, IFN-γ, NF-kB, and IL-1β production, (6) alteration of the dysregulated intestinal microbiota in CD. Bifidobacterium longum IATA-ES1, B. lactis, B. bifidum IATA-ES2, and B. lactis Natren Life Start super strain (NLS-SS) are the most frequently cited strains benefiting celiac individuals.

Conclusão

The revised mechanisms highlighted Bifidobacterium-derived probiotics' possible probiotic effect in managing CD. However, further studies must clarify the gaps for each proposed mechanism.