Dados do Trabalho

Título

BLOOD METABOLOMIC ANALYSIS OF MICE TRATED WITH PASSION FRUIT SOLUBLE DIETARY FIBERS

Introdução

Chronic non-communicable diseases represent a serious public health problem as they are responsible for the high rate of disability and mortality in the global population. In this context, it is known that a healthy diet plays a fundamental role in the prevention and treatment of chronic metabolic diseases. Passion fruit peel (Passiflora edulis) is rich in dietary fibers which presents gastroprotective effect against stomach ulcers and in reducing the severity of ulcerative colitis, regulating oxidative stress and inflammation and strengthening the intestinal protective barrier. Given the above and considering the wide range of publications that report the therapeutic effects of passion fruit, the hypothesis of our work was to evaluate the influence of passion fruit soluble dietary fiber consumption on the metabolic profile of mice.

Material e Métodos

Female mice were daily orally treated with saline (control group, n=8) or with 100 mg/kg of passion fruit soluble dietary fiber (SDF group, n=9), for 8 days. Then, the blood was collected, centrifuged and the plasma was subjected to LC-MS analysis.

Resultados e Discussão

Trigoneline and 1-methylnicotinamide were metabolites found in high concentration in plasma samples of SDF group.

Conclusão

Trigoneline is an alkaloid found in several plants and it is also a product of niacin metabolism. Literature reports several therapeutic effects associated with trigonelline, including anti-diabetic effect, neuroprotective action (in conditions like Alzheimer's, Parkinson's, dementia, and depression), cardioprotective, hepatoprotective, anti-cancer activity and skin protection. 1-Methylnicotinamide belongs to the class of organic compounds present in all living species, being found in foods, and the literature reports antithrombotic activity, inhibiting platelet-dependent thrombosis, thus demonstrating regulatory potential in thrombotic and inflammatory processes of the cardiovascular system, anti-inflammatory properties in the management of skin disorders such as acne and dermatitis due to its topical application. Our results demonstrated that in addition to the therapeutic properties already demonstrated by the administration of passion fruit soluble dietary fibers against various diseases, the oral treatment with these polysaccharides can also influence the blood metabolic profile of the treated animals.