Dados do Trabalho

Título

APPLICABILITY OF CARBOXYMETHYLCELLULOSE/CHITOSAN MICRO-PECS IN THE ENCAPSULATION AND CONTROLLED RELEASE OF NIACINAMIDE

Introdução

Supramolecular structures formed by biopolymers have attracted interest due to their distinctive properties, especially in biomedical and food fields. Encapsulation of bioactive compounds in these structures can enhance their stability and efficacy, being a valuable strategy for developing controlled release systems.

Material e Métodos

In this study, carboxymethylcellulose/chitosan (CMC/CHS) micro-PECs were prepared by simultaneously adding dispersions of CMC and CHS biopolymers, with niacinamide, under different pH conditions, niacinamide concentration, and mixing time. Niacinamide, a form of vitamin B3, was chosen for its well-documented benefits in skincare, including its role in reducing inflammation, regulating oil production, and improving the skin barrier function, making it a compelling candidate for inclusion in the study.

Resultados e Discussão

Results showed variable encapsulation efficiency of niacinamide, with significant influence from pH, niacinamide concentration, and reaction time. Encapsulation efficiency ranged from 0.86% to 80.78%, while loading capacity ranged from 0.03% to 3.89%. Both (encapsulation efficiency and loading capacity) were mainly affected by pH. Release kinetics results indicated that niacinamide release primarily occurs through diffusion, with slower release rates at lower pH levels. Release models suggested that niacinamide release is predominantly diffusion-dependent, with slower rates at lower pH due to the formation of more compact structures. Furthermore, in vitro digestibility of CMC/CHS micro-PECs containing niacinamide was evaluated using a static gastrointestinal model. Four kinetic models were fitted to niacinamide release kinetics data: Zero Order, First Order, Higuchi, and Korsemeyer-Peppas. The zero-order model exhibited the best fit at all points, with low zero-order constants (K0 = 0.002 - 0.003), indicating a low release rate. In conclusion, the results indicate that CMC/CHS micro-PECs showed adequacy as niacinamide delivery systems, offering potential for applications in food and pharmaceutical products. Additional investigation is now on the way to assess the stability and applicability of these systems in more complex formulations.

Conclusão

In conclusion, the results indicate that CMC/CHS micro-PECs showed adequacy as niacinamide delivery systems, offering potential for applications in food and pharmaceutical products. Additional investigation in now on the way to assess the stability and applicability of these systems in more complex formulations.