Dados do Trabalho

Título

IN VIVO EFFECT OF CINNAMALDEHYDE ON EDEMATOGENIC PARAMETERS IN AN EXPERIMENTAL ARTHRITIS MODEL

Introdução

Arthritis is a condition characterised by joint inflammation, resulting in chronic hyperalgesia, edema, and limitation of daily movements. In search of alternative treatments, natural compounds have been explored. An example is cinnamaldehyde (CIN), a phenylpropanoid found in cinnamon (Cinnamomum sp.) known for its antioxidant and antimicrobial properties. This study aimed to evaluate the potential effect of CIN in reducing pathology developed in a rat arthritis model.

Material e Métodos

Treatment of animals with CIN began 14 days after arthritis induction by injection (100 µL) of complete Freund adjuvant (CFA). Animals were divided into four groups (n=4): control (C); cinnamaldehyde (CIN); arthritis (ART); and arthritis treated with CIN (ART+CIN). CIN was administered at 2.1% by daily gavage for 14 days. CIN was freshly prepared in corn oil and administered (1 mL/kg) between 9 and 11 AM. After the treatment period, animals were euthanized with isoflurane. Ankle joint tissues were isolated for histopathological analysis. To investigate the potential anti-edematogenic effect of repeated CIN administration, we evaluated arthritis score development, paw edema, and thermal hyperalgesia.

Resultados e Discussão

Results showed that arthritis-induced groups had a significant increase in disease score and edema compared to the control group. However, the ART+CIN group showed a significant reduction in thermal hyperalgesia, indicating a possible analgesic effect of the compound, although other parameters did not show statistically significant differences compared to the ART group. The healthy group receiving CIN showed no alterations in the tests conducted. ART groups exhibited significant infiltration of neutrophils and lymphocytes. However, ART+CIN resulted in some alterations in collagen fibres, along with lymphocytic infiltrate.

Conclusão

In conclusion, cinnamaldehyde demonstrated potential to reduce thermal hyperalgesia in a rat arthritis model, suggesting an analgesic effect. Histopathological studies demonstrate a curious and positive effect of CIN in reducing infiltrated neutrophil levels, which may have beneficial effects in the long term. Therefore, further studies will be necessary to fully elucidate the mechanisms and efficacy of cinnamaldehyde as a proposed therapeutic for inflammation and edema.